Phenibut 101


Phenibut was developed back in the 1960’s in Russia¹.  It is a unique product and some will say that it is not technically a nootropic. It is primarily used for its calming effects rather than as a cognitive enhancer.   Though some claim that it does have cognition enhancing/nootropic effects. It is often used in “stacks” alongside other nootropics.

Phenibut Powder

Phenibut Powder

How Does It Work

Phenibut was developed to mimic GABA. GABA is a natural neurotransmitter. As you can see in the images below their chemical makeup is very similar, the difference being that Phenibut adds a phenyl ring .



Phenibut c


What this phenyl component does is allow it to get pass the blood-brain barrier, where as GABA by itself cannot.

It has been also shown to improve dopamine levels.

Benefits and Uses

As stated before it is usually used for its calming and anti-stress properties. But has also been shown to be helpful in some other aspects as well. Here is a list of the known benefits:

  • Relieve Tension
  • Help with Anxiety
  • Reduce Fear
  • Improve Sleep
  • Pre/Post Operative medication
  • Help with Stuttering and Vestibular disorders
  • Post-Traumatic Stress
  • Improving Mood
  • Slight increase in helping with memory

It has been also shown to increase dopamine levels.


As with most products and supplements dosage can vary depending on the individual, and a variety of other factors. It would be best to consult an actual doctor/physician on this matter. With that being said a typical dosage is usually between 200-1,000 mg.

You should also take note that it can take up to 4 hrs to feel effects after taking Phenibut. So you don’t want to be to quick at re-dosing.

And as always it is best to start with a low dosage and work your way up till you find your tolerance level.

Possible Side Effects

With anything and everything there is the possibility of side effects. This is another reason to start out at a smaller dose.

Here is a list that includes some of the known side effects:

  • Nausea
  • Dizziness
  • Gastrointestinal distress
  • Loss in Memory
  • Euphoria feeling
  • Tiredness


Phenibut looks to be an intriguing supplement. Especially for those whose suffer from anxiety and stress. It also appears that it would make for a great addition to a nootropic stack. Although this product was developed in the 60’s it is still rather “new”. Further testing should indicate its true potential or unlikely demise.

This product is on my list to test and try, and I’ve actually already have a 100g tub sitting here waiting to try after I finish up my trial of noopept.




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